Epidemiological Trends in Opioid-Only and Opioid/Polysubstance-Related Death Rates Among American Indian/Alaska Native Populations from 1999 to 2019: A Retrospective Longitudinal Ecological Study

The rate of drug overdose deaths in the USA has more than tripled since the turn of the century, and rates are disproportionately high among the American Indian/Alaska Native (AI/AN) population. Little is known about the overall historical trends in AI/AN opioid-only and opioid/polysubstance-related mortality. This study will address this gap.